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Knowledge Base Article
Streptamer for CD8+ T-cell staining
Reversible, antigen-specific T-cell staining
The Streptamer technology is a novel method to isolate and characterise functional antigen-specific T-cells. Streptamers enable for the first time a reversible, antigen specific staining of T-cells, leaving the isolated T-cells phenotypically and functionally indistinguishable from untreated cells. Streptamer-isolated T-cells may offer new strategies for treating uncurable diseases including viral infections and cancer by adoptive T-cell transfer. In addition, the technology is likely to advance basic T-cell research as an essential prerequisite for novel immunological medicines. The technology was developed in cooperation with Dirk H. Busch, TU Munich. His experiments in mice (Knabel et al.) demonstrate that the Streptamer technology is capable to provide antigen-specific T-cells, which efficiently can be applied in adoptive transfer protocols.
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Streptamer reversible staining and isolation of functional T-cells |
| streptamerflyer2007_lowres.pdf, 522Kb | |
| Streptamer Cell TAGnologies brochure |
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Streptamer Manual |
| PR22_Streptamer_Manual_0001.pdf, 488Kb | |
| Antigen-specific staining and functional isolation of T-Cells |
