Join us at the magnificently-refurbished Palace Hotel in the heart of Manchester on Tuesday 8th June or at the prestigious Queen Elizabeth II Conference Centre, close to the Palace of Westminster in central London on Thursday 10th June.
Plenary sessions will introduce the Thermo Fisher Scientific brand and illustrate how the world’s broadest portfolio of products can help you make the world a healthier, cleaner and safer place.
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»» Thermo Scientific UK Summer Symposium
Thermo Fisher Scientific Accelerates Drug Discovery Process with New Maybridge Quick2Lead™ Compound Kits
Fast, simple and convenient building block kits advance hit-to-lead programmes
TINTAGEL, UK (17 March 2009) – Thermo Fisher Scientific, the world leader in serving science, announced today that it has introduced a novel tool to accelerate hit-to-lead programmes in the drug discovery process. Its Maybridge Quick2Lead™ Compound Kits are designed to save time and money by enabling rapid compound library synthesis around bioactive “hits” emerging from screening assays. The kits are made up of pre-weighed, diverse building block selections, facilitating rapid capture of structure-activity (SAR) data from the closely related structural analogues within the library.
Quick2Lead Compound Kits are available as five functionality-based kits, with each one containing 48 carefully selected compounds. This enables the exploration of a wide area of chemical space to maximise credible SAR data acquisition for the successful conversion of an initial hit into a genuine, optimisable lead. Since these compounds are all pre-weighed, the kits are ready to use by simply adding solvent and transferring straight to a synthesiser.
»» Accelerate Drug Discovery Process with Maybridge Quick2Lead Compound Kits
Thermo Fisher Scientific Maybridge Fragments Selected by Nordlund Centre for Biomedical Structural Biology
Maybridge Ro3 500 Fragment Library to support establishment of new fragment screening-based drug discovery platform
TINTAGEL, UK (March 9, 2010) – Thermo Fisher Scientific, the world leader in serving science, today announced that the Nordlund Centre for Biomedical Structural Biology at Nanyang Technological University in Singapore has purchased its Maybridge Ro3 500 Fragment Library. Nordlund will use this “off-the-shelf” set of 500 pharmacophorically-rich Maybridge compounds as a benchmark fragment library to optimize structure-based screening methods for a diverse set of drug candidates. The ultimate objective of the project is to understand the optimal screening protocols for different protein target families and to publish these results for the scientific and drug discovery community.
The new Nordlund Centre, based in the prestigious Biopolis hub in Singapore, is headed by Professor Pär Nordlund, a renowned structural biologist and visiting professor from the Karolinska Institute in Stockholm. Through this comparative study, the Nordlund team will establish a platform for the efficient generation of chemical probes using fragment-based methods. The six- to nine-month study will guide researchers and the entire industry on the preferred fragment screening technique for several protein classes.
The study includes seven protein classes, including HsP90. The group will assess fragment binding in each protein class using a range of standard techniques, including ITC, NMR, SPR, DSF and X-ray crystallography.
“We selected the Maybridge Fragment library as a benchmark for our comparative study as it is a globally renowned and industry recognised set of diverse and high-quality compounds,” said Dr. Andreas Larsson, project leader within the Nordlund group. “Of particular interest to us was the validated aqueous solubility data provided by Maybridge scientists, where solubility checks up to five mMol in aqueous phosphate buffer have been measured.”
»» Maybridge Fragments Selected by Nordlund Centre
Due to the recent ruling from The International Union of Pure and Applied Chemistry (IUPAC); the definition of the Mole will change commencing today 01-04-2010.
The old definition of the Mole, ‘The amount of a substance that contains as many atoms, molecules, ions, or other elementary units as the number of atoms in 0.012 Kilogram of carbon 12.
The number is 6.0225 × 1023, or Avogadro’s number’ is now redundant. The change has come about due to the re-evaluation of the definition of the number of entities in 0.012Kg if pure Carbon 12 following recent studies at the Large Hadron Collider in Geneva. The Higgs Boson has now been included in the definition.
It is thought that with a ratio of 3 Higgs Bosons per Proton or Neutron, Avagadro’s Number now stands at 18.067 × 1023.
Make sure you read the following…
»» Mole will change commencing today 01-04-2010
In February 2010 Fisher Scientific opened a new office in Vantaa, near Helsinki, Finland. After other recent office openings in Sweden, Norway and Denmark, ensuring Fisher Scientific has a strong presence within the Nordic countries.
Fisher Scientific’s presence in Finland ensures that research scientists, technicians, purchasing professionals and all those involved within procuring laboratory supplies have fast, easy access to more than 350,000 products, serviced through a full warehouse onsite. Customers can browse and purchase items via www.fishersci.fi, which will be available in the spring of 2010.
The Finland office reflects the country’s strong values of environmental stewardship and responsibility. In 2010, the office plans to launch a “green” product portfolio to meet the needs of environmentally conscious customers in the region.
Minna Gröning, sales manager for Fisher Scientific Finland, commented:
“We are very pleased to open an office in Finland to serve the Finnish laboratory community with a high-quality and innovative service concept.”
