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	<title>Science News from the Fisher Scientific Blog &#187; Medical Science</title>
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	<link>http://www.fisher.co.uk/science-news</link>
	<description>Science News from the Fisher Scientific Blog</description>
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		<title>Most MS patients &#8216;missing out on drugs&#8217;</title>
		<link>http://www.fisher.co.uk/science-news/industry-news/most-ms-patients-missing-out-on-drugs/</link>
		<comments>http://www.fisher.co.uk/science-news/industry-news/most-ms-patients-missing-out-on-drugs/#comments</comments>
		<pubDate>Sun, 19 May 2013 17:12:36 +0000</pubDate>
		<dc:creator>Tania</dc:creator>
				<category><![CDATA[Industry News]]></category>
		<category><![CDATA[Life Science]]></category>
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		<guid isPermaLink="false">http://www.fisher.co.uk/science-news/?p=6976</guid>
		<description><![CDATA[New research indicates that 60 per cent of multiple sclerosis (MS) patients are not taking a disease-modifying drug (DMD). This could be putting their health and wellbeing at rest, and will potentially have a significantly negative impact on future quality of life. The NHS estimates that 100,000 people in the UK are affected by the [...]]]></description>
			<content:encoded><![CDATA[<h3><img src="http://www.fisher.co.uk/science-news/wp-content/uploads/2013/05/iStock_000008414974XSmall-150x150.jpg" alt="" title="iStock_000008414974XSmall" width="150" height="150" class="alignright size-thumbnail wp-image-6997" />New research indicates that 60 per cent of multiple sclerosis (MS) patients are not taking a disease-modifying drug (DMD). This could be putting their health and wellbeing at rest, and will potentially have a significantly negative impact on future quality of life.<span id="more-6976"></span></h3>
<p>The NHS estimates that 100,000 people in the UK are affected by the neurological condition, and the MS Society report entitled A lottery of treatment and care: MS services across the UK showcases considerable discrepancies between the care administered to patients.</p>
<p>The largest-ever survey of MS sufferers in the country suggests healthcare workers are failing to provide these people with the treatment and assistance they need to maintain a higher level of independence.</p>
<p>The condition results when a person&#39;s immune system, which is responsible for destroying harmful pathogens in attempts to prevent infection, mistakenly identifies the body&#39;s own tissues as harmful and begins to attack them.</p>
<p>In the case of MS, these cells destroy the myelin which surrounds nerves. This insulates and protects the fibres, and damage or elimination results in serious problems with the nervous and neurological system.</p>
<p>Patients often experience loss of vision since nerves cannot effectively communicate this type of information to the brain, while issues with mobility, coordination and numbness are also often witnessed.</p>
<p>A significant number of people require assistance with their MS through the provision of home adaptations, wheelchairs and other aids, although the charity found that there is somewhat of a &#39;postcode lottery&#39; when it comes to distribution of help.</p>
<p>Director for policy and research Nick Rijke said: &quot;Our survey findings worryingly suggest that the likelihood of someone receiving a life changing treatment or service is often based on luck &ndash; like where they live or how helpful their healthcare professional is &ndash; rather than their genuine clinical need.&quot;</p>
<p>In attempts to promote the provision of tailored and effective care to all MS patients, the organisation has launched an e-petition. It wants the UK to increase MS drug prescription rates and improve provision of aid so that patients benefit from a superior quality of life.</p>
<div id="crp_related"><h3>Related Posts:</h3><ul><li><a href="http://www.fisher.co.uk/science-news/industry-news/home-care-resources-could-reduce-nhs-strain/" rel="bookmark" class="crp_title">Home care resources could reduce NHS strain</a></li><li><a href="http://www.fisher.co.uk/science-news/industry-news/genes-reveal-which-patients-respond-well-to-scleroderma-drug/" rel="bookmark" class="crp_title">Genes reveal which patients respond well to scleroderma drug</a></li><li><a href="http://www.fisher.co.uk/science-news/chemicalscience/leukaemia-drug-eases-multiple-sclerosis-symptoms/" rel="bookmark" class="crp_title">Leukaemia drug eases multiple sclerosis symptoms</a></li><li><a href="http://www.fisher.co.uk/science-news/industry-news/eye-test-helps-monitor-multiple-sclerosis-patients/" rel="bookmark" class="crp_title">Eye test helps monitor multiple sclerosis patients</a></li><li><a href="http://www.fisher.co.uk/science-news/industry-news/diabetes-patients-failing-to-follow-self-care-guidelines/" rel="bookmark" class="crp_title">Diabetes patients &#8216;failing to follow self-care guidelines&#8217;</a></li></ul></div>]]></content:encoded>
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		<title>Vaccination programme to protect over-70s from shingles</title>
		<link>http://www.fisher.co.uk/science-news/lifescience/vaccination-programme-to-protect-over-70s-from-shingles/</link>
		<comments>http://www.fisher.co.uk/science-news/lifescience/vaccination-programme-to-protect-over-70s-from-shingles/#comments</comments>
		<pubDate>Sat, 18 May 2013 20:10:12 +0000</pubDate>
		<dc:creator>Tania</dc:creator>
				<category><![CDATA[Life Science]]></category>
		<category><![CDATA[Medical Science]]></category>
		<category><![CDATA[Proteomics]]></category>
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		<guid isPermaLink="false">http://www.fisher.co.uk/science-news/?p=6978</guid>
		<description><![CDATA[UK residents aged 70 or over may be eligible to take advantage of a new vaccination programme which is being launched in September. The healthcare initiative is being introduced to help lower the incidence rates associated with shingles in the country. The NHS estimates that three in every 1,000 people are affected by the condition [...]]]></description>
			<content:encoded><![CDATA[<h3><img src="http://www.fisher.co.uk/science-news/wp-content/uploads/2013/04/Shingles-150x150.jpg" alt="" title="Shingles" width="150" height="150" class="alignright size-thumbnail wp-image-7053" />UK residents aged 70 or over may be eligible to take advantage of a new vaccination programme which is being launched in September. The healthcare initiative is being introduced to help lower the incidence rates associated with shingles in the country.</p>
<p>The NHS estimates that three in every 1,000 people are affected by the condition each year, with prevalence highest in the over-50s. The infection is caused when the herpes varicella-zoster virus, which causes chicken pox, is reactivated later in life.</p>
<p>A vaccination called Zostavax can reduce a person&#39;s chance of contracting the condition by 50 to 70 per cent, according to the healthcare provider, although patients today will usually have to fund the jab privately.</p>
<p>However, the new programme will see over-70s, who are most prone to complications, routinely administered the vaccination. BBC News reports that 800,000 elderly people in England will be protected in the first year alone.</p>
<p>The vaccine works by introducing a weakened form of the virus into the recipient&#39;s body. This allows the immune system to generate antibodies which destroy the disease without threat of serious infection.</p>
<p>Memory cells retain the coding information required to produce these pathogen-fighting proteins, and are activated in the event of reinfection. This means that the immune system is more quickly equipped to fight off the virus.</p>
<p>It should prevent many people from suffering the symptoms, which include exhaustion, a painful rash and fever, as well as complications such as transverse myelitis (inflammation of the spinal cord) and scarring of the cornea.</p>
<p>Since the vaccination should help to prevent many hospitalisations, the Department of Health estimated that the programme will save the organisation &pound;20 million per year. It is thought that the scheme will cost &pound;25 million annually to implement.</p>
<p>University of Bristol&#39;s Professor Adam Finn told the BBC: &quot;There&#39;s a cost involved in both buying and giving the vaccines but there&#39;s also enormous savings from all the disease that you prevent. Not only suffering and some deaths but also all the costs of hospitalisation, not to mention all the inconvenience, people taking time off work to look after their children and so on and so forth.&quot;</p>
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		<title>Healthcare texts &#8216;improve self-care in asthmatic children&#8217;</title>
		<link>http://www.fisher.co.uk/science-news/industry-news/healthcare-texts-improve-self-care-in-asthmatic-children/</link>
		<comments>http://www.fisher.co.uk/science-news/industry-news/healthcare-texts-improve-self-care-in-asthmatic-children/#comments</comments>
		<pubDate>Sat, 18 May 2013 17:04:43 +0000</pubDate>
		<dc:creator>Tania</dc:creator>
				<category><![CDATA[Cell Biology]]></category>
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		<guid isPermaLink="false">http://www.fisher.co.uk/science-news/?p=6980</guid>
		<description><![CDATA[Self-care is an extremely important aspect of the treatment course in asthmatic patients, and new research indicates that the well being of children with the condition could be improved if they were simply sent a relevant text message each day. Researchers from the Georgia Institute of Technology replicated conditions of a study presented at the [...]]]></description>
			<content:encoded><![CDATA[<h3><div id="attachment_5889" class="wp-caption alignright" style="width: 160px"><img src="http://www.fisher.co.uk/science-news/wp-content/uploads/2013/01/320px-Asthma_-150x150.jpg" alt="" title="Asthma Obstruction of the lumen of the bronchiole " width="150" height="150" class="size-thumbnail wp-image-5889" /><p class="wp-caption-text">Attribution: Yale Rosen</p></div>Self-care is an extremely important aspect of the treatment course in asthmatic patients, and new research indicates that the well being of children with the condition could be improved if they were simply sent a relevant text message each day.</p>
<p>Researchers from the Georgia Institute of Technology replicated conditions of a study presented at the Proceedings of the Second ACM SIGHIT International Health Informatics Symposium in order to determine whether communicating with young patients in this way was beneficial.</p>
<p>Investigators recruited 30 asthmatic ten to 17-year-olds who were attending a private pediatric pulmonology clinic and randomly assigned them into three different groups so that they could compare the effects of different experimental conditions.</p>
<p>One set of participants was sent a text message per day, which prompted them to consider their symptoms or provided them a piece of information concerning the respiratory illness. Another received this communication every other day.</p>
<p>The remaining subjects acted as a control group, and were not sent any messages. Researchers ensured that all children involved were able to understand the texts by checking that they had attained a certain reading level.</p>
<p>Investigators then analysed clinical outcomes of the youngsters by looking at healthcare records and gaining information from physicians, and cross-referenced outcomes of each group to determine whether there were any significant trends.</p>
<p>Findings revealed that sending one text message per day was associated with improved wellbeing. This might involve lower incidence of symptoms, such as coughing, wheezing, tightness in the chest or breathlessness.</p>
<p>Lead author of the study Rosa Arriaga said: &quot;It appears that text messages acted as an implicit reminder for patients to take their medicine and by the end of the study, the kids were more in tune with their illness.&quot;</p>
<p>Findings were presented at the ACM SIGCHI Conference on Human Factors in Computing Systems 2013, and could have implications in terms of treating other illnesses. Many patients could benefit from prompts which motivate them to take their medicine.</p>
<p>According to the World Health Organization (WHO), half of people fail to take drugs correctly. This could be having a hugely detrimental impact on their quality of life.</p>
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		<title>Breast cancer cases in under-50s at record high</title>
		<link>http://www.fisher.co.uk/science-news/industry-news/breast-cancer-cases-in-under-50s-at-record-high/</link>
		<comments>http://www.fisher.co.uk/science-news/industry-news/breast-cancer-cases-in-under-50s-at-record-high/#comments</comments>
		<pubDate>Sat, 18 May 2013 10:28:00 +0000</pubDate>
		<dc:creator>Tania</dc:creator>
				<category><![CDATA[Cell Biology]]></category>
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		<guid isPermaLink="false">http://www.fisher.co.uk/science-news/?p=6984</guid>
		<description><![CDATA[The number of breast cancer cases in women under 50 in the UK has surpassed 10,000, meaning that incidence in this age group is at a record high. Cancer Research UK found that one-in-five diagnoses of the disease relate to these younger females, despite age being such a significant risk factor. The findings indicate that [...]]]></description>
			<content:encoded><![CDATA[<h3><img src="http://www.fisher.co.uk/science-news/wp-content/uploads/2011/10/iStock_000009444336XSmall-150x150.jpg" alt="Cancer Cell" title="Cancer Cell" width="150" height="150" class="alignright size-thumbnail wp-image-1611" />The number of breast cancer cases in women under 50 in the UK has surpassed 10,000, meaning that incidence in this age group is at a record high.<span id="more-6984"></span></h3>
<p>Cancer Research UK found that one-in-five diagnoses of the disease relate to these younger females, despite age being such a significant risk factor.</p>
<p>The findings indicate that the younger generation is increasingly engaging in other risky lifestyle practices, such as unhealthy levels of alcohol intake.</p>
<p>People who are overweight or obese are also more likely to develop the condition, and research indicates that the population&#39;s average body-mass index&nbsp;(BMI) has been increasing in recent decades.</p>
<p>Researchers also believe that adapting attitudes to childbirth, including increased use of the contraceptive pill, could be impacting hormone levels and, therefore, contributing to risk.</p>
<p>However, medical advancements and improvements to healthcare mean that a growing number of women are experiencing favourable outcomes following a breast cancer diagnosis.</p>
<p>The charity&#39;s director of health information Sara Hiom said: &quot;Thanks to research, awareness and improved care more women than ever before are surviving the disease.&quot;</p>
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		<title>Statin drugs may reduce prostate cancer risk</title>
		<link>http://www.fisher.co.uk/science-news/chemicalscience/statin-drugs-may-reduce-prostate-cancer-risk/</link>
		<comments>http://www.fisher.co.uk/science-news/chemicalscience/statin-drugs-may-reduce-prostate-cancer-risk/#comments</comments>
		<pubDate>Fri, 17 May 2013 17:52:16 +0000</pubDate>
		<dc:creator>Tania</dc:creator>
				<category><![CDATA[Cell Biology]]></category>
		<category><![CDATA[Chemical Science]]></category>
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		<guid isPermaLink="false">http://www.fisher.co.uk/science-news/?p=6983</guid>
		<description><![CDATA[Statins are a type of medication which help reduce levels of low-density lipoprotein (LDL) cholesterol in the blood, and as such can lower the risk of cardiovascular problems like heart attack and stroke. However, new research indicates that the drugs could also have implications in reducing a person&#39;s chance of developing cancer. A research team [...]]]></description>
			<content:encoded><![CDATA[<h3><img src="http://www.fisher.co.uk/science-news/wp-content/uploads/2012/03/iStock_000000371304XSmall-150x150.jpg" alt="Prostate Cancer Slide" title="Prostate Cancer Slide" width="150" height="150" class="alignright size-thumbnail wp-image-3473" />Statins are a type of medication which help reduce levels of low-density lipoprotein (LDL) cholesterol in the blood, and as such can lower the risk of cardiovascular problems like heart attack and stroke. However, new research indicates that the drugs could also have implications in reducing a person&#39;s chance of developing cancer.<span id="more-6983"></span></h3>
<p>A research team led by Dr &nbsp;Janet L Stanford, co-director of the Prostate Cancer Research Program at the Fred Hutchinson Cancer Research Center, conducted an investigation in order to determine whether this trend was scientifically measurable. The results were published in the online journal The Prostate.</p>
<p>Scientists recruited more than 1,000 participants into their experiment, all of whom had been diagnosed with the potentially life-threatening disease, which affects approximately 40,000 and kills around 10,000 men in the UK every year. They asked about their medication, and then followed their health outcomes for eight years so that they could cross-reference the data.</p>
<p>Analysts found that the risk of death from prostate cancer was one per cent in the group of subjects who were taking statins. Those patients who were not taking the cholesterol-lowering drugs had a five-times higher chance of fatality.</p>
<p>However, lead author Milan S Geybels MSc, who is based at Maastricht University, explained that the results must be verified through further investigation in order to justify administration of statins as an anti-prostate cancer treatment. Prescribing them needlessly is dangerous, since side-effects like inflammation and insomnia sometimes arise.</p>
<p>He said: &quot;[Statins] cannot be recommended for the prevention of prostate cancer-related death until a preventive effect on mortality from prostate cancer has been demonstrated in a large, randomised, placebo-controlled clinical trial.&quot;</p>
<p>Cholesterol plays an indirect role in the survival of diseased cells, and so taking statins may help to reduce the size of tumours and prevent development of aggressive, fatal growths. However, the exact biological mechanisms behind the apparent link are currently unknown. Geybels said &quot;any compound that could stop or slow the progression of prostate cancer would be beneficial&quot;.</p>
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		<title>Female smokers &#8216;at highest colon cancer risk&#8217;</title>
		<link>http://www.fisher.co.uk/science-news/industry-news/female-smokers-at-highest-colon-cancer-risk/</link>
		<comments>http://www.fisher.co.uk/science-news/industry-news/female-smokers-at-highest-colon-cancer-risk/#comments</comments>
		<pubDate>Fri, 17 May 2013 13:05:15 +0000</pubDate>
		<dc:creator>Tania</dc:creator>
				<category><![CDATA[Industry News]]></category>
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		<guid isPermaLink="false">http://www.fisher.co.uk/science-news/?p=6981</guid>
		<description><![CDATA[New research indicates that women may be more biologically vulnerable to the colon cancer-causing effects of smoking. Females who smoke fewer cigarettes than males may still be at a higher risk of developing the disease. Scientists from the University of Tromso analysed data concerning more than 600,000 19 to 67-year-olds which had been gathered by [...]]]></description>
			<content:encoded><![CDATA[<h3><img src="http://www.fisher.co.uk/science-news/wp-content/uploads/2013/04/cigarette-150x150.jpg" alt="" title="cigarette" width="150" height="150" class="alignright size-thumbnail wp-image-6888" />New research indicates that women may be more biologically vulnerable to the colon cancer-causing effects of smoking. Females who smoke fewer cigarettes than males may still be at a higher risk of developing the disease.</p>
<p>Scientists from the University of Tromso analysed data concerning more than 600,000 19 to 67-year-olds which had been gathered by the Norwegian Institute of Public Health. The data spanned 14 years, giving analysts opportunity to look for long-term trends.</p>
<p>They analysed colon cancer rates in the group, and cross-referenced incidence to smoking habits in order to determine whether there were any significant trends. They then calculated the risk applicable to each gender.</p>
<p>Findings revealed that women increased their chance of developing the disease by 19 per cent if they took up the unhealthy habit, although smoking upped men&#39;s likelihood of colon cancer by eight per cent.</p>
<p>The length of time a woman had been smoking correlated to the risk, with those who had retained the habit for 40 years or more having a 50 per cent higher chance of developing the potentially fatal condition.</p>
<p>This could also be linked to age, since the NHS claims that more than seven-in-ten patients are 65 or older. Approximately 40,000 people in the UK are affected by this condition every year &#8211; it is the third most common form of cancer.</p>
<p>However, the investigators did not take confounding factors such as diet and alcohol consumption into consideration with their calculations, meaning that smoking may not be the sole factor behind women&#39;s increased likelihood of developing colon cancer.</p>
<p>Diet, exercise levels, alcohol consumption and genes may all play a role in causing this condition, and women may be more prone to engaging in these risk activities, especially if they are smokers.</p>
<p>Dr Stephanie Bernik, chief of surgical oncology at Lenox Hill Hospital, told HealthDay: &quot;Usually, smoking goes along with other bad health habits. However, this adds to the growing data that cigarette smoking contributes to the increased risk of colon cancer.&quot;</p>
<div id="crp_related"><h3>Related Posts:</h3><ul><li><a href="http://www.fisher.co.uk/science-news/industry-news/smoking-one-cigarette-daily-may-double-sudden-death-risk/" rel="bookmark" class="crp_title">Smoking one cigarette daily may double sudden death risk</a></li><li><a href="http://www.fisher.co.uk/science-news/industry-news/female-smokers-who-quit-by-30-could-eliminate-death-risk/" rel="bookmark" class="crp_title">Female smokers who quit by 30 could eliminate death risk</a></li><li><a href="http://www.fisher.co.uk/science-news/industry-news/smoking-in-the-morning-increases-lung-cancer-risk-further/" rel="bookmark" class="crp_title">Smoking in the morning &#8216;increases lung cancer risk further&#8217;</a></li><li><a href="http://www.fisher.co.uk/science-news/industry-news/lower-risk-of-bacterial-pneumonia-among-non-smoking-hiv-patients/" rel="bookmark" class="crp_title">Lower risk of bacterial pneumonia among non-smoking HIV patients</a></li><li><a href="http://www.fisher.co.uk/science-news/industry-news/heavy-smoking-may-increase-the-risk-of-aggressive-bladder-cancer/" rel="bookmark" class="crp_title">Heavy smoking may increase the risk of aggressive bladder cancer</a></li></ul></div>]]></content:encoded>
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		<title>Milk allergy linked to chalk dust hypersensitivity</title>
		<link>http://www.fisher.co.uk/science-news/industry-news/milk-allergy-linked-to-chalk-dust-hypersensitivity/</link>
		<comments>http://www.fisher.co.uk/science-news/industry-news/milk-allergy-linked-to-chalk-dust-hypersensitivity/#comments</comments>
		<pubDate>Fri, 17 May 2013 08:51:41 +0000</pubDate>
		<dc:creator>Tania</dc:creator>
				<category><![CDATA[Industry News]]></category>
		<category><![CDATA[Life Science]]></category>
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		<guid isPermaLink="false">http://www.fisher.co.uk/science-news/?p=6982</guid>
		<description><![CDATA[New research indicates that children who are allergic to milk may also be hypersensitive to chalk dust, meaning they are prone to adverse reactions while at school. A study published by the American College of Allergy, Asthma and Immunology (ACAAI) reveals that the milk protein which can trigger an allergic response, casein, is also present [...]]]></description>
			<content:encoded><![CDATA[<h3><img src="http://www.fisher.co.uk/science-news/wp-content/uploads/2013/02/calcium-150x150.jpg" alt="glass of milk" title="glass of milk" width="150" height="150" class="alignright size-thumbnail wp-image-6362" />New research indicates that children who are allergic to milk may also be hypersensitive to chalk dust, meaning they are prone to adverse reactions while at school.<span id="more-6982"></span></h3>
<p>A study published by the American College of Allergy, Asthma and Immunology (ACAAI) reveals that the milk protein which can trigger an allergic response, casein, is also present in blackboard chalks.</p>
<p>Even though they claim to be dustless products, these chalks emit invisible particles which, when inhaled, could cause respiratory irritation in sensitive children.</p>
<p>According to Allergy UK, one-in-50 infants are affected by a milk allergy, compared to one-in-1,000 older children, meaning a significant number of students are at risk.</p>
<p>Chair of the ACAAI Indoor Environment Committee Dr James Sublett said: &quot;Milk proteins can also be found in glue, paper, ink, and in other children&#39;s lunches.&quot;</p>
<p>Parents can help protect their children from experiencing symptoms like wheezing and vomiting by checking nutritional labels on food, asking for their child to be sat at the back of the class, and talking to their doctor about antihistamine medication.</p>
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		<title>Explanations found for cholesterol drug side effects</title>
		<link>http://www.fisher.co.uk/science-news/industry-news/explanations-found-for-cholesterol-drug-side-effects/</link>
		<comments>http://www.fisher.co.uk/science-news/industry-news/explanations-found-for-cholesterol-drug-side-effects/#comments</comments>
		<pubDate>Wed, 15 May 2013 14:49:26 +0000</pubDate>
		<dc:creator>Tania</dc:creator>
				<category><![CDATA[Industry News]]></category>
		<category><![CDATA[Life Science]]></category>
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		<guid isPermaLink="false">http://www.fisher.co.uk/science-news/?p=6987</guid>
		<description><![CDATA[Reasons behind the side effects of cholesterol-lowering drugs have been identified in new research from the University of Arizona (UA). The US Food and Drug Administration, as well as physicians, have documented that some patients using statins, a class of global top-selling drugs used to lower cholesterol, have experienced fuzzy thinking and reversible memory loss. [...]]]></description>
			<content:encoded><![CDATA[<h3><img src="http://www.fisher.co.uk/science-news/wp-content/uploads/2013/05/iStock_000008414974XSmall-150x150.jpg" alt="" title="iStock_000008414974XSmall" width="150" height="150" class="alignright size-thumbnail wp-image-6997" />Reasons behind the side effects of cholesterol-lowering drugs have been identified in new research from the University of Arizona (UA).<span id="more-6987"></span></h3>
<p>The US Food and Drug Administration, as well as physicians, have documented that some patients using statins, a class of global top-selling drugs used to lower cholesterol, have experienced fuzzy thinking and reversible memory loss.</p>
<p>A study from the UA research team has revealed that brain cells being treated with statin drugs can experience unusual swellings within neurons, which was termed the &lsquo;beads-on-a-string&rsquo; effect.</p>
<p>The reasons behind the formation of such beads was not ascertained, however the team is hoping that further investigation will explain why some people experience cognitive declines following the taking of statin medication.</p>
<p>UA neuroscientist Professor Linda L Restifo, who is leading the investigation, said: &ldquo;What we think we&rsquo;ve found is a laboratory demonstration of a problem in the neuron that is a more severe version for what is happening in some peoples&rsquo; brains when they take statins.&rdquo;</p>
<p>The findings of Professor Restifo and her team&rsquo;s co-authored study have this month been published in peer-reviewed journal Disease Models &amp; Mechanisms.</p>
<p>Within the article clinical reports are cited, which note that statin users are often told by physicians that any cognitive disturbances are likely due to ageing or other effects. This latest research offers additional evidence that the reasons for declines in cognition are due to a negative response to the statin medication.&nbsp;</p>
<p>Removing the statins was shown to restore normal growth and stop the beads-on-a-string effect from occurring, however it is thought that genetics may be involved in the bead formation and that such variations could result in different effects on neurons.</p>
<p>Also commenting on the results, Professor David M Labiner, who heads the UA department of neurology, explained: &ldquo;If we can figure out a way to identify patients who will have certain side effects, we can improve therapeutic outcomes.&rdquo;</p>
<p>Professor Restifo added: &ldquo;If we are able to do genetic studies, the goal will be to come up with a predictive test so that a patient with high cholesterol could be tested first to determine whether they have a sensitivity to statins.&rdquo;</p>
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		<title>Non-inherited mutations ‘could account for heart defects’</title>
		<link>http://www.fisher.co.uk/science-news/lifescience/non-inherited-mutations-could-account-for-heart-defects/</link>
		<comments>http://www.fisher.co.uk/science-news/lifescience/non-inherited-mutations-could-account-for-heart-defects/#comments</comments>
		<pubDate>Wed, 15 May 2013 09:52:22 +0000</pubDate>
		<dc:creator>Tania</dc:creator>
				<category><![CDATA[Cell Biology]]></category>
		<category><![CDATA[Life Science]]></category>
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		<guid isPermaLink="false">http://www.fisher.co.uk/science-news/?p=6988</guid>
		<description><![CDATA[A genomics study led by researchers at Yale University&#8217;s School of Medicine and funded by the National Heart, Lung and Blood Institute (NHLBI) has found that new mutations which are absent in parents but appear in their offspring account for more than ten per cent of severe congenital heart disease cases. Congenital heart disease is [...]]]></description>
			<content:encoded><![CDATA[<h3><img src="http://www.fisher.co.uk/science-news/wp-content/uploads/2013/02/shutterstock_52636333-150x150.jpg" alt="Heart Disease" title="Heart Disease" width="150" height="150" class="alignright size-thumbnail wp-image-6152" />A genomics study led by researchers at Yale University&rsquo;s School of Medicine and funded by the National Heart, Lung and Blood Institute (NHLBI) has found that new mutations which are absent in parents but appear in their offspring account for more than ten per cent of severe congenital heart disease cases.<span id="more-6988"></span></h3>
<p>Congenital heart disease is the most common form of birth defect and affects nearly one per cent of all newborns.</p>
<p>In an analysis of all the genes of more than 1,800 individuals, researchers found hundreds of mutations that can cause the condition, with the most frequent mutations in genes being those that modify histones. These are crucial to the development of the foetus.</p>
<p>The results of the study, which is part of the Pediatric Cardiac Genomics Consortium, were published this week in the journal Nature and offer a new insight into the causes of common congenital disease.</p>
<p>Dr Gary H Gibbons, who is director of the NHLBI, commented on the results and described the study as &ldquo;an important piece of the puzzle that gives us a clearer picture of the causes of congenital heart disease&rdquo;.</p>
<p>He added: &ldquo;What this international, multi-centre collaborative research effort was able to accomplish, in a small amount of time, is truly remarkable. The state-of-the-art sequencing techniques that were used are allowing us to push the envelope and envision a day when we may be able to better treat and eventually prevent congenital heart disease in the early stages of heart formation.&rdquo;</p>
<p>It was discovered that the mutations can occur simultaneously and can both increase and decrease the modification of vital histone proteins.</p>
<p>This suggests that this very sensitive developmental system could also be influenced by a series of environmental factors in its development and points to that fact that there are fundamental mechanisms which play a role in a wide range of congenital diseases.</p>
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		<title>Ambient noise in the operating theatre &#8216;breeds miscommunication&#8217;</title>
		<link>http://www.fisher.co.uk/science-news/industry-news/ambient-noise-in-the-operating-theatre-breeds-miscommunication/</link>
		<comments>http://www.fisher.co.uk/science-news/industry-news/ambient-noise-in-the-operating-theatre-breeds-miscommunication/#comments</comments>
		<pubDate>Tue, 14 May 2013 19:38:13 +0000</pubDate>
		<dc:creator>Tania</dc:creator>
				<category><![CDATA[Industry News]]></category>
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		<guid isPermaLink="false">http://www.fisher.co.uk/science-news/?p=6989</guid>
		<description><![CDATA[New research reveals that ambient noise in the operating theatre can result in miscommunication and, therefore, compromise patient outcomes. The study, which was published in the Journal of the American College of Surgeons, shows that healthcare professionals should take extra measures to control their working conditions. Researchers created sound environments comparable to those typically found [...]]]></description>
			<content:encoded><![CDATA[<h3><img src="http://www.fisher.co.uk/science-news/wp-content/uploads/2013/05/operating-theatre-2-150x150.jpg" alt="" title="operating-theatre-2" width="150" height="150" class="alignright size-thumbnail wp-image-6990" />New research reveals that ambient noise in the operating theatre can result in miscommunication and, therefore, compromise patient outcomes. The study, which was published in the Journal of the American College of Surgeons, shows that healthcare professionals should take extra measures to control their working conditions.<span id="more-6989"></span></h3>
<p>Researchers created sound environments comparable to those typically found in the operating room and tested performance of 15 surgeons. They analysed comprehension of participants using Speech In Noise Test-Revised (SPIN-R) under four different sound conditions and cross-referenced outcomes.</p>
<p>Findings indicated that music significantly hindered the experts&#39; ability to hear and understand colleagues&#39; speech when they were engaged in a task. Difficulties are amplified when people are discussing information that is unpredictable, such as a drug dosage.</p>
<p>Medical errors frequently result from miscommunication, since it is vital that the healthcare workers properly understand which and how much of a drug needs to be administered, what instruments the surgeon requires and so on.</p>
<p>A BBC investigation has shown that more than 750 NHS patients have experienced a &#39;never event&#39; &#8211; a preventable surgical error &#8211; in the past four years. Incidents include the leaving behind of instruments inside a patient&#39;s body and operation on the wrong body part.</p>
<p>Tackling these kinds of issues could therefore have a significant impact on improving patient outcomes, improving hospitalisation, morbidity and mortality rates while preventing unnecessary waste of resources in the healthcare system.</p>
<p>Study co-author Dr Matthew Bush, assistant professor of surgery at the University of Kentucky Medical Center, said: &quot;The operating room is a very fast-paced, high-demand, all senses running on all cylinders type of environment.</p>
<p>&quot;To minimise errors of communication, it is essential that we consider very carefully the listening environment we are promoting in the operating room. The surgical team needs to work diligently to create the safest environment possible, and that step may mean either turning the music off or down.&quot;</p>
<p>Researchers plan to further their understanding of this effect by investigating the consequences of ambient noise on the performance of other workers, such an anaesthetists, in the operating theatre.</p>
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